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Literature summary for 5.1.1.18 extracted from

  • Sikka, P.; Walker, R.; Cockayne, R.; Wood, M.J.; Harrison, P.J.; Burnet, P.W.
    D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO) (2010), J. Neurosci. Res., 88, 1829-1840.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information SRR overexpression increases D-serine and pyruvate and decreases D-serine uptake and alanine-serine-cysteine transporter ASCT2 mRNA but does not affect D-amino acid oxidase. SRR knockdown does not alter any of the parameters Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
 x * 38000, about, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine Rattus norvegicus
-
 D-serine D-serine is an endogenous N-methyl-D-aspartate, NMDA, receptor coagonist ?
additional information Rattus norvegicus regulation of the D-serine content in the forebrain and in C6 glioma cells, that lack the main degerative enzyme D-amino acid oxidase, might act via mechanisms including SRR operating in alpha,beta-eliminase mode, converting D-serine to pyruvate, and regulation by serine transport, in which the alanine-serine-cysteine transporter ASCT2 is implicated, overview. D-serine transport mediated by ASCT2 contributes prominently to D-serine homeostasis when DAO activity is absent ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q76EQ0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C6 glioma cell
-
 Rattus norvegicus
-
forebrain
-
 Rattus norvegicus
-
glioma cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
 Rattus norvegicus D-serine
-
 ?
L-serine
-
 Rattus norvegicus D-serine D-serine is an endogenous N-methyl-D-aspartate, NMDA, receptor coagonist ?
additional information regulation of the D-serine content in the forebrain and in C6 glioma cells, that lack the main degerative enzyme D-amino acid oxidase, might act via mechanisms including SRR operating in alpha,beta-eliminase mode, converting D-serine to pyruvate, and regulation by serine transport, in which the alanine-serine-cysteine transporter ASCT2 is implicated, overview. D-serine transport mediated by ASCT2 contributes prominently to D-serine homeostasis when DAO activity is absent Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 38000, about, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
SRR
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus L-serine or D-serine, but not D-proline, increase the expression of SRR in C6 cells when added to the cell culture medium up