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Literature summary for 5.1.1.18 extracted from

  • Inoue, R.; Hashimoto, K.; Harai, T.; Mori, H.
    NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice (2008), J. Neurosci., 28, 14486-14491.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine serine racemase is the major enzyme for D-serine production in the brain, D-serine is the predominant endogenous coagonist of the NMDA receptor in the forebrain, and D-serine may be involved in controlling the extent of NMDA receptor-mediated neurotoxic insults observed in disorders including Alzheimer's disease. Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information serine racemase knock-out mice show a 90% decrease in forebrain D-serine content and a reduced neurotoxicity induced by NMDA- and beta-amyloid1-42-peptide injections in the forebrain Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus serine racemase is the major enzyme for D-serine production in the brain, D-serine is the predominant endogenous coagonist of the NMDA receptor in the forebrain, and D-serine may be involved in controlling the extent of NMDA receptor-mediated neurotoxic insults observed in disorders including Alzheimer’s disease. ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information serine racemase is the major enzyme for D-serine production in the brain, D-serine is the predominant endogenous coagonist of the NMDA receptor in the forebrain, and D-serine may be involved in controlling the extent of NMDA receptor-mediated neurotoxic insults observed in disorders including Alzheimer’s disease. Mus musculus ?
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