Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Mus musculus | |
ATP | 1 mM, decrease of Km-value for racemization by 85%, allosteric mechanism. Inhibitory to L-serine O-sulfate dehydration reaction | Mus musculus | |
GTP | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.8 | - |
L-serine | racemization reaction, isoform A, pH 8.6, 37°C | Mus musculus | |
13 | - |
L-serine | racemization reaction, isoform A, presence of ATP, pH 8.6, 37°C | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | may partially replace Mg2+ | Mus musculus | |
Mg2+ | required by both isoforms A and B | Mus musculus | |
Mn2+ | may partially replace Mg2+ | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
isoforms A and B, gel filtration | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isoforms A and B, bifunctional enzymes, racemization of serine and elimination of L-serine and L-serine-O-sulfate to form pyruvate | - |
Purification (Comment) | Organism |
---|---|
both isoforms A and B | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | - |
Mus musculus | pyruvate + NH3 | - |
? | |
L-serine | - |
Mus musculus | D-serine | - |
r | |
L-serine O-sulfate | - |
Mus musculus | O-sulfopyruvate + NH3 | - |
? |