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Literature summary for 5.1.1.11 extracted from
- Active thiol-directed binding and adsorption of gramicidin S-synthetase I to disulfide-containing matrices (1986), Biochim. Biophys. Acta, 883, 345-352.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cystamine | Mg2+ alone or in combination with the substrates ATP and Phe causes significant protection. Cystamine-inactivated enzyme can be reactivated by treatment with dithioerythritol or other sulfhydryl compounds. 0.5 M cystamine causes 90%, 40% and 30% loss in activity if preincubated at 37°C, 20°C, or 0°C for 20 min | Brevibacillus brevis |  |
| cysteamine | - |
Brevibacillus brevis | |
| DL-cystine | - |
Brevibacillus brevis | |
| N,N'-Diacetylcystamine | - |
Brevibacillus brevis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brevibacillus brevis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Phe + H2O | - |
Brevibacillus brevis | AMP + diphosphate + D-Phe | - |
? | |
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