Literature summary for 5.1.1.10 extracted from

Foltyn, V.N.; Bendikov, I.; De Miranda, J.; Panizzutti, R.; Dumin, E.; Shleper, M.; Li, P.; Toney, M.D.; Kartvelishvily, E.; Wolosker, H.
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity (2005), J. Biol. Chem., 280, 1754-1763.

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Activating Compound

Activating Compound	Comment	Organism	Structure
ATP	-	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
H152S	ratio of elimination reaction to racemization is 1.4 compared to 3.7 in wild-type	Mus musculus
N154F	ratio of elimination reaction to racemization is 0.33 compared to 3.7 in wild-type	Mus musculus
P153S	ratio of elimination reaction to racemization is 0.24 compared to 3.7 in wild-type	Mus musculus
Q155D	ratio of elimination reaction to racemization is 0.25 compared to 3.7 in wild-type	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	bifunctional enzymes, racemization of serine and alpha,beta-elimination of L-serine	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-serine	alpha,beta-elimination reaction	Mus musculus	pyruvate + NH3	-	?
D-serine	racemization reaction	Mus musculus	L-serine	-	r
L-serine	alpha,beta-elimination reaction	Mus musculus	pyruvate + NH3	-	?
L-serine	racemization reaction	Mus musculus	D-serine	-	r
L-threonine	alpha,beta-elimination reaction	Mus musculus	2-oxobutyrate + NH3	-	?
additional information	ration of elimination reaction/racemization reaction for substrate L-serine is 3.7	Mus musculus	?	-	?

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Release 2023.1 (January 2023)