Literature summary for 5.1.1.1 extracted from

Spies, M.A.; Toney, M.D.
Multiple hydrogen kinetic isotope effects for enzymes catalyzing exchange with solvent: application to alanine racemase (2003), Biochemistry, 42, 5099-5107.

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Organism

Organism	UniProt	Comment	Textmining
Geobacillus stearothermophilus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Arg	stepwise mechanism for alanine racemase at both 25°C and at 65°C. The carbanionic intermediate is obligatory, and Arg219 may serve to destabilize it to avoid side reactions such as transamination, a detailed reaction mechanism is proposed that includes enzyme and substrate protonation states	Geobacillus stearothermophilus	D-Arg	-	r

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Release 2023.1 (January 2023)