Inhibitors | Comment | Organism | Structure |
---|---|---|---|
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate | - |
Bacillus anthracis | |
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate | - |
Bordetella pertussis | |
methylanthraniloyl-ATP | - |
Bacillus anthracis | |
methylanthraniloyl-ATP | - |
Bordetella pertussis | |
methylanthraniloyl-CTP | - |
Bacillus anthracis | |
methylanthraniloyl-CTP | - |
Bordetella pertussis | |
methylanthraniloyl-GTP | - |
Bacillus anthracis | |
methylanthraniloyl-GTP | - |
Bordetella pertussis | |
methylanthraniloyl-ITP | - |
Bacillus anthracis | |
methylanthraniloyl-ITP | - |
Bordetella pertussis | |
methylanthraniloyl-UTP | - |
Bacillus anthracis | |
methylanthraniloyl-UTP | - |
Bordetella pertussis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0125 | - |
CTP | in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
0.0686 | - |
CTP | in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bordetella pertussis | |
0.4197 | - |
CTP | in the presence of 5 mM Mg2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Bacillus anthracis | |
Mn2+ | required | Bordetella pertussis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Bordetella pertussis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP | - |
Bordetella pertussis | 3',5'-cyclic CMP + diphosphate | - |
? | |
CTP | - |
Bacillus anthracis | 3',5'-cyclic CMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CyaA | also possesses cytidylyl cyclase activity | Bordetella pertussis |
cytidylyl cyclase | - |
Bordetella pertussis |
cytidylyl cyclase | - |
Bacillus anthracis |
Edema factor | also possesses cytidylyl cyclase activity | Bacillus anthracis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
CTP | in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bordetella pertussis | |
7.2 | - |
CTP | in the presence of 5 mM Mg2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
8.8 | - |
CTP | in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000011 | - |
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bordetella pertussis | |
0.0000011 | - |
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
0.0000045 | - |
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
0.00008 | - |
methylanthraniloyl-CTP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
0.00058 | - |
methylanthraniloyl-ATP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
0.001 | - |
methylanthraniloyl-ITP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bordetella pertussis | |
0.0013 | - |
methylanthraniloyl-CTP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bordetella pertussis | |
0.0018 | - |
methylanthraniloyl-UTP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bordetella pertussis | |
0.0028 | - |
methylanthraniloyl-GTP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
0.0038 | - |
methylanthraniloyl-UTP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
0.0044 | - |
methylanthraniloyl-ATP | in 75 mM HEPES-NaOH, pH 7.4,at 37°C | Bordetella pertussis | |
0.0057 | - |
methylanthraniloyl-ITP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
0.0061 | - |
methylanthraniloyl-GTP | in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bordetella pertussis |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.37 | - |
CTP | in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bordetella pertussis | |
17.2 | - |
CTP | in the presence of 5 mM Mg2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis | |
704 | - |
CTP | in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C | Bacillus anthracis |