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Literature summary for 4.6.1.2 extracted from

  • Gong, R.; Ding, C.; Hu, J.; Lu, Y.; Liu, F.; Mann, E.; Xu, F.; Cohen, M.B.; Luo, M.
    Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior (2011), Science, 333, 1642-1646.
    View publication on PubMed
Search for more literature for 4.6.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
midbrain guanylyl cyclase-C protein is expressed predominantly on the somata and dendrites of dopaminergic neurons in the the midbrain ventral tegmental area and substantia nigra compacta Mus musculus
-
neuron midbrain dopamine neuron Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic-GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
GC-C
-
 Mus musculus
guanylyl cyclase-C
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Mus musculus

General Information

General Information Comment Organism
malfunction guanyl cyclase-C-knockout mice exhibit hyperactivity and attention deficits Mus musculus
physiological function guanyl cyclase-C activation potentiates the excitatory responses mediated by glutamate and acetylcholine receptors via the activity of GMP-dependent protein kinase Mus musculus