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Literature summary for 4.6.1.2 extracted from

  • Makino, R.; Park, S.Y.; Obayashi, E.; Iizuka, T.; Hori, H.; Shiro, Y.
    Oxygen binding and redox properties of the heme in soluble guanylate cyclase: implications for the mechanism of ligand discrimination (2011), J. Biol. Chem., 286, 15678-15687.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Bos taurus 3',5'-cyclic-GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Bos taurus
soluble guanylate cyclase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
heme the weak Fe2+-proximal His bond is a key determinant for the low O2 affinity of the heme moiety of soluble guanylate cyclase Bos taurus

General Information

General Information Comment Organism
physiological function soluble guanylate cyclase is an NO-sensing hemoprotein that serves as a nitric oxide receptor in nitric oxide-mediated signaling pathways Bos taurus