Activating Compound | Comment | Organism | Structure |
---|---|---|---|
nitric oxide | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1H-(1,2,4)oxadiazole(4,3-a)quinoxalin-1one | - |
Homo sapiens | |
1H-[1,2,4]oxadiazolo[4.3a]quinoxalin-1-one | inhibition of the enzyme is blocked by 8-bromo-cGMP or L-arginine | Homo sapiens | |
additional information | inhibition of the enzyme is involved in inhibition of tumor cell migration in lung | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Homo sapiens | the enzyme and cGMP-pathway are involved in NO-mediated cell migration | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Homo sapiens | - |
3',5'-cyclic-GMP + diphosphate | - |
? | |
additional information | Homo sapiens | inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
adenocarcinoma cell | - |
Homo sapiens | - |
large cell lung cancer cell line | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | the enzyme and cGMP-pathway are involved in NO-mediated cell migration | Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Homo sapiens | 3',5'-cyclic-GMP + diphosphate | - |
? | |
additional information | inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2, overview | Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | guanylate cyclase plays a role in migration of A-549 cells | Homo sapiens |