Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.2 extracted from

  • Nagayama, T.; Zhang, M.; Hsu, S.; Takimoto, E.; Kass, D.A.
    Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil (2008), J. Pharmacol. Exp. Ther., 326, 380-387.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
BAY 41-8543 i.e. 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)pyrimidine-4,6-diamine, a sGC stimulator Mus musculus
additional information NO-independent sGC activation is synergistic with NO-sGC stimulation Mus musculus
NO activates sGC Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus the regulation of arterial vasodilatory and cardiac beta-adrenergic reserve by phosphodiesterase type 5-I targets cGMP from soluble GC stimulation 3',5'-cyclic GMP + diphosphate
-
 ?
additional information Mus musculus sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male adult C57/Bl6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP the regulation of arterial vasodilatory and cardiac beta-adrenergic reserve by phosphodiesterase type 5-I targets cGMP from soluble GC stimulation Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
additional information sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Mus musculus
soluble guanylate cyclase
-
 Mus musculus