Protein Variants | Comment | Organism |
---|---|---|
additional information | the depletion of sGC by RNA interference fails to prevent Y-27632- and staurosporine-induced neurite outgrowth | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one | i.e. ODQ, inhibits the enzyme, and also inhibits Y-27632- and staurosporine-induced neurite outgrowth and triggered neurite retraction, but in an sGC-independent manner. The NO/sGC/cGMP signaling cascade is not, but the the ERK signaling pathway is critically involved in ODQ-induced neurite remodeling | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
neurite | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Homo sapiens | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
additional information | Homo sapiens | the NO/sGC/cGMP signaling cascade is not critically involved in ODQ-induced neurite remodeling, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
additional information | the NO/sGC/cGMP signaling cascade is not critically involved in ODQ-induced neurite remodeling, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Homo sapiens |
soluble guanylyl cyclase | - |
Homo sapiens |