Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.2 extracted from

  • Morton, D.B.; Stewart, J.A.; Langlais, K.K.; Clemens-Grisham, R.A.; Vermehren, A.
    Synaptic transmission in neurons that express the Drosophila atypical soluble guanylyl cyclases, Gyc-89Da and Gyc-89Db, is necessary for the successful completion of larval and adult ecdysis (2008), J. Exp. Biol., 211, 1645-1656.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Cloned(Commentary)

Cloned (Comment) Organism
gene encoding isozyme Gyc-89Da, expression analysis and promoter analysis, expression in Saccharomces cerevisiae Drosophila melanogaster
gene encoding isozyme Gyc-89Db, expression analysis and promoter analysis, expression in Saccharomces cerevisiae Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information generation of an isozyme Gyc-89Da deficient mutant, reduced levels of cGMP in Gyc-89Da neurons have no effect on larval ecdysis or eclosion, but isozyme expression is necessary early in adult development to prevent eclosion, phenotype, overview Drosophila melanogaster
additional information generation of an isozyme Gyc-89Db deficient mutant, reduced levels of cGMP in Gyc-89Db neurons have no effect on larval ecdysis or eclosion, but isozyme expression is necessary early in adult development to prevent eclosion, phenotype, overview Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
tetanus toxin expression of tetanus toxin in the neurons, that express isozyme Gyc-89Da, blocks their synaptic activity; expression of tetanus toxin in the neurons, that express isozyme Gyc-89Db, blocks their synaptic activity Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
synapse
-
 Drosophila melanogaster 45202
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Drosophila melanogaster isozyme Gyc-89Da in neurons is necessary early in adult development to prevent eclosion, overview 3',5'-cyclic GMP + diphosphate
-
 ?
GTP Drosophila melanogaster isozyme Gyc-89Db in neurons is necessary early in adult development to prevent eclosion, overview 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VEU5
-
-
Drosophila melanogaster Q9VEU6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron the isozyme Gyc-89Da is encoded in neurons that are required for larval and adult ecdyses in the fruit fly Drosophila melanogaster
-
neuron the isozyme Gyc-89Db is encoded in neurons that are required for larval and adult ecdyses in the fruit fly Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Drosophila melanogaster 3',5'-cyclic GMP + diphosphate
-
 ?
GTP isozyme Gyc-89Da in neurons is necessary early in adult development to prevent eclosion, overview Drosophila melanogaster 3',5'-cyclic GMP + diphosphate
-
 ?
GTP isozyme Gyc-89Db in neurons is necessary early in adult development to prevent eclosion, overview Drosophila melanogaster 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Gyc-89Da
-
 Drosophila melanogaster
Gyc-89Db
-
 Drosophila melanogaster
soluble guanylyl cyclase
-
 Drosophila melanogaster