Literature summary for 4.6.1.2 extracted from

Frey, R.; Mueck, W.; Unger, S.; Artmeier-Brandt, U.; Weimann, G.; Wensing, G.
Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: an ascending-dose study in healthy male volunteers (2008), J. Clin. Pharmacol., 48, 926-934.

Search for more literature for 4.6.1.2

Activating Compound

Activating Compound	Comment	Organism	Structure
BaY 63-2521	i.e. methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-ylmethylcarbamate, analysis of safety, tolerability, pharmacokinetics, and pharmacodynamics and pharmacodynamic effects of the compound, which is beneficial in reduction of blood pressure, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP	Homo sapiens	-	3',5'-cyclic GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	male	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Homo sapiens	3',5'-cyclic GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sGC	-	Homo sapiens
soluble guanylate cyclase	-	Homo sapiens

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Release 2023.1 (January 2023)