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Literature summary for 4.6.1.2 extracted from

  • Marro, M.L.; Peiro, C.; Panayiotou, C.M.; Baliga, R.S.; Meurer, S.; Schmidt, H.H.; Hobbs, A.J.
    Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor (2008), J. Biol. Chem., 283, 20027-20036.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Cloned(Commentary)

Cloned (Comment) Organism
quantitative analysis of promoter activity and determination of transcriptional start sites within the 5'-flanking region of alpha1 and beta1 sGC using transiently transfected luciferase reporter constructs, expression in human aortic smooth muscle cells and in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens soluble guanylyl cyclase is the principal receptor for NO and plays a ubiquitous role in regulating cellular function, sGC governs smooth muscle tone and growth, vascular permeability, leukocyte flux, and platelet aggregation. Aberrant NO-sGC signaling is linked to diseases including hypertension, atherosclerosis, and stroke 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta human aortic smooth muscle cells Homo sapiens
-
blood vessel
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
smooth muscle cell vascular Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
GTP soluble guanylyl cyclase is the principal receptor for NO and plays a ubiquitous role in regulating cellular function, sGC governs smooth muscle tone and growth, vascular permeability, leukocyte flux, and platelet aggregation. Aberrant NO-sGC signaling is linked to diseases including hypertension, atherosclerosis, and stroke Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Homo sapiens
soluble guanylyl cyclase
-
 Homo sapiens