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Literature summary for 4.6.1.2 extracted from

  • Schmidt, H.H.; Schmidt, P.M.; Stasch, J.P.
    NO- and haem-independent soluble guanylate cyclase activators (2009), Handb. Exp. Pharmacol., 191, 309-339.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
BAY 58-2667 activates the NO- and haem-independent soluble guanylate cyclase, the compound is capable of selectively activating the oxidized/haem-free enzyme via binding to the enzyme's haem pocket, causing pronounced vasodilatation Homo sapiens
HMR 1766 activates the NO- and haem-independent soluble guanylate cyclase, compound is capable of selectively activating the oxidized/haem-free enzyme via binding to the enzyme's haem pocket, causing pronounced vasodilatation Homo sapiens

Application

Application Comment Organism
pharmacology activators of sGC may be beneficial in the treatment of a range of diseases including systemic and pulmonary hypertension, heart failure, atherosclerosis, peripheral arterial occlusive disease, thrombosis and renal fibrosis, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information NO- and haem-independent soluble guanylate cyclase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
vascular system
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
NO- and haem-independent sGC
-
 Homo sapiens
NO- and haem-independent soluble guanylate cyclase
-
 Homo sapiens
sGC
-
 Homo sapiens
soluble guanylate cyclase
-
 Homo sapiens