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Literature summary for 4.6.1.2 extracted from

  • Matsuda, N.M.; Lemos, M.C.; Feitosa, R.L.
    The effect of guanylate cyclase inhibitors on non-adrenergic and non-cholinergic neurogenic relaxations of the South American opossum lower esophageal sphincter (2008), Fundam. Clin. Pharmacol., 22, 299-304.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information electrical field stimulation partially activates the enzyme and induces smooth muscle relaxation, overview Didelphis albiventris
NO
-
Didelphis albiventris

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo[4,3a]quinoxalin-1-one i.e. ODQ Didelphis albiventris
cystamine
-
Didelphis albiventris
LY 83583 i.e. 6-anilino-5,8-quinoledione Didelphis albiventris
methylene blue
-
Didelphis albiventris

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Didelphis albiventris 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Didelphis albiventris
-
3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Didelphis albiventris
-
South American opossum, female and male
-

Source Tissue

Source Tissue Comment Organism Textmining
esophagus lower esophageal sphincter circular smooth muscle Didelphis albiventris
-
smooth muscle lower esophageal sphincter circular smooth muscle Didelphis albiventris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Didelphis albiventris 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
sGC
-
Didelphis albiventris
soluble guanylate cyclase
-
Didelphis albiventris