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Literature summary for 4.6.1.2 extracted from
- Characterization of oxidized guanosine 5-triphosphate as a viable inhibitor of soluble guanylyl cyclase (2009), Free Radic. Biol. Med., 46, 828-835.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NO | - |
Rattus norvegicus |  |
| NO | - |
Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 8-oxoguanosine triphosphate | i.e. oxo8GTP, a potent inhibitor of nitric oxide-stimulated soluble guanylyl cyclase | Bos taurus | |
| 8-oxoguanosine triphosphate | i.e. oxo8GTP, a potent competitive inhibitor of nitric oxide-stimulated soluble guanylyl cyclase | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Rattus norvegicus | - |
- |
| soluble | - |
Bos taurus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | Rattus norvegicus | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | Bos taurus | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | purified sGC from lung | Bos taurus | - |
| lung | - |
Bos taurus | - |
| PC-12 cell | adrenal medulla derived cell line | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | - |
Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sGC | - |
Rattus norvegicus |
| sGC | - |
Bos taurus |
| soluble guanylyl cyclase | - |
Rattus norvegicus |
| soluble guanylyl cyclase | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
| 37 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
| 7.4 | - |
assay at | Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Rattus norvegicus | |
| additional information | - |
additional information | inhibition kinetics | Bos taurus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.288 | - |
pH 7.4, 37°C, in presence of 0.05 mM GTP | Rattus norvegicus | 8-oxoguanosine triphosphate | |
| 1.8 | - |
pH 7.4, 37°C, in presence of 0.5 mM GTP | Rattus norvegicus | 8-oxoguanosine triphosphate | |
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