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Literature summary for 4.6.1.2 extracted from

  • Vazquez-Padron, R.I.; Pham, S.M.; Mateu, D.; Khan, S.; Aitouche, A.
    An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase beta2 mRNA translation (2008), FEBS J., 275, 3598-3607.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
isolation of two mRNA species for sGC beta2 with dissimilar 5'-untranslated regions from human kidney, translational mechanism of the sGC beta2-subunit, overview. Insertion of these regions between the two luciferase genes of a bicistronic vector and transfection into HeLa cells, both sGC beta2 leaders have internal ribosome entry site, IRES, activity in a cell-type dependent manner. The sGC beta2 IRES is functional in a wide range of cell lines, e.g. HeLa cells, Hep-G2 cells, COS-7 cells, and CCL-185 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75343
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?

Subunits

Subunits Comment Organism
dimer a heterodimer consisting of an alpha- and beta-subunit, the secondary structural model of the sGC beta2 5'-UTR predicts a Y-type pseudoknot Homo sapiens

Synonyms

Synonyms Comment Organism
sGC
-
Homo sapiens
soluble guanylyl cyclase
-
Homo sapiens