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Literature summary for 4.6.1.2 extracted from

  • Grimminger, F.; Weimann, G.; Frey, R.; Voswinckel, R.; Thamm, M.; Boelkow, D.; Weissmann, N.; Mueck, W.; Unger, S.; Wensing, G.; Schermuly, R.T.; Ghofrani, H.A.
    First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension (2009), Eur. Respir. J., 33, 785-792.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
riociguat i.e. BAY 63-2521, a soluble guanylate cyclase stimulator, acts directly, stimulates the enzyme, and increases the sensitivity to low NO levels. It significantly improves pulmonary haemodynamic parameters and cardiac index in patients with pulmonary hypertension Homo sapiens

Application

Application Comment Organism
medicine the enzyme stimulation, e.g. by riociguat, is a strategy in treatment of pulmonary hypertension, moderate-to-severe phenotype, associated with impaired production of the vasodilator nitric oxide, study of safety, tolerability and efficacy in patients Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Homo sapiens
soluble guanylate cyclase
-
 Homo sapiens