Activating Compound | Comment | Organism | Structure |
---|---|---|---|
BAY 41-2272 | an allosteric activator | Rattus norvegicus | |
NO | binding of NO to sGC leads to the formation of a five-coordinate ferrous-nitrosyl complex and a several hundred-fold increase in cGMP synthesis, the NO activation of sGC is influenced by GTP and the allosteric activators YC-1 and BAY 41-2272, analysis of the Fe-NO conformation, overview | Rattus norvegicus | |
YC-1 | an allosteric activator | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression of wild-type alpha1beta2 sGC enzyme in Spodoptera frugiperda Sf9 cells, and of heme domain mutants in Escherichia coli | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of heme domain mutant comprising residues beta1(1-194) or beta2(1-217) | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | part of the heme cofactor, analysis of the Fe-NO conformation, overview | Rattus norvegicus | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Rattus norvegicus | - |
3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Rattus norvegicus |
soluble guanylate cyclase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | sGC is a hemoprotein | Rattus norvegicus |