Literature summary for 4.6.1.2 extracted from

Ro, J.Y.; Lee, J.; Capra, N.F.; Zhang, Y.
Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity (2007), Brain Res., 1184, 141-148.

Search for more literature for 4.6.1.2

Application

Application	Comment	Organism
medicine	NO-sGC pathway in the subnucleus caudalis is involved in mediating orofacial muscle hypersensitivity under acute inflammatory condition	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
1H-[1,2,4]oxadiazolo[4,3-a]-quinoxalin-1-one	specific sGC inhibitor, significantly blocks the capsaicin-induced reduction of mechanical threshold to noxious stimulation of the masseter	Rattus norvegicus
methylene blue	non-specific sGC inhibitor, significantly blocks the capsaicin-induced reduction of mechanical threshold to noxious stimulation of the masseter	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
77000	-	beta1 subunit of sGC, Western blot analysis	Rattus norvegicus
82000	-	beta1 subunit of sGC, Western blot analysis	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	brainstem, subnucleus caudalis, where it is present in neuronal cell bodies in the superficial laminae and in astrocytes in deeper lamina	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
sGC	-	Rattus norvegicus
soluble guanylate cyclase	-	Rattus norvegicus

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Release 2023.1 (January 2023)