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Literature summary for 4.6.1.2 extracted from
- Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo (2006), Br. J. Pharmacol., 149, 797-801.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| atrial natriuretic peptide | - |
Mus musculus | |
| atrial natriuretic peptide | - |
Homo sapiens | |
| NO | - |
Mus musculus |  |
| NO | - |
Homo sapiens | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | crosstalk occurs between the NO-sGC and atrial natriuretic peptide-pGC pathways to regulate cGMP-dependent vasodilatation in vivo | Mus musculus |
| medicine | crosstalk occurs between the NO-sGC and atrial natriuretic peptide-pGC pathways to regulate cGMP-dependent vasodilatation in vivo | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | endothelial NO synthase and natriuretic peptide receptor-A knockout mice, sodium nitroprusside and atrial natriuretic peptide produce enhanced dose-dependent reductions in mean arterial blood pressure in endothelial NO synthase knockout mice. In natriuretic peptide receptor-A knockout mice, sodium nitroprusside produces a dose-dependent reduction in mean arterial blood pressure that is significantly higher than that in wild-type mice. Responsiveness to the cAMP-dependent vasodilator epoprostenol is similar in wild-type, endothelial NO synthase and natriuretic peptide receptor-A knockout animals. Atrial natriuretic peptide causes vasodilatation of the forearm resistance vasculature that is significantly higher in individuals lacking endothelium-derived NO | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
C57/BL6 mice | - |
| Mus musculus C57BL/6 | - |
C57/BL6 mice | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| particulate guanylate cyclase | - |
Mus musculus |
| particulate guanylate cyclase | - |
Homo sapiens |
| PGC | - |
Mus musculus |
| PGC | - |
Homo sapiens |
| sGC | - |
Mus musculus |
| sGC | - |
Homo sapiens |
| soluble guanylate cyclase | - |
Mus musculus |
| soluble guanylate cyclase | - |
Homo sapiens |
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