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Literature summary for 4.6.1.2 extracted from

  • Veltman, D.M.; Bosgraaf, L.; van Haastert, P.J.M.
    Unusual guanylyl cyclases and cGMP signaling in Dictyostelium discoideum (2004), Vitam. Horm., 69, 95-115.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
GTPgammaS stimulates activity of guanylyl cyclase GCA by lowering the KM-value of GTP and increasing the Vmax, half-maximal stimulation at 0.011 mM Dictyostelium discoideum
GTPgammaS stimulates activity of soluble guanylyl cyclase (sGC) by lowering the KM-value of GTP and increasing the Vmax, half-maximal stimulation at 0.008 mM Dictyostelium discoideum

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Dictyostelium discoideum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
 GTP guanylyl cyclase GCA Dictyostelium discoideum
0.414
-
 GTP soluble guanylyl cyclase sGC Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Dictyostelium discoideum 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ guanylyl cyclase GCA is about 5fold more active with optimal Mg2+ concentrations than with optimal Mn2+ concentrations Dictyostelium discoideum
Mg2+ soluble guanylyl cyclase sGC is about 6fold more active with 2 mM Mn2+ than with 2 mM Mg2+ Dictyostelium discoideum
Mn2+ guanylyl cyclase GCA is about 5fold more active with optimal Mg2+ concentrations than with optimal Mn2+ concentrations Dictyostelium discoideum
Mn2+ soluble guanylyl cyclase sGC is about 6fold more active with 2 mM Mn2+ than with 2 mM Mg2+ Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Dictyostelium discoideum soluble guanylyl cyclase sGC provides the major guanylyl cyclase activity in Dictyostelium, contributing about 90% of the chemoattractant-induced cGMP response ?
-
 ?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
 GCA, another guanylyl cylase, i.e. soluble guanylyl cyclase (sGC), is present in Dictyostelium
-
Dictyostelium discoideum
-
 soluble guanylyl cyclase (sGC), another guanylyl cylase, i.e. GCA, is present in Dictyostelium
-

Source Tissue

Source Tissue Comment Organism Textmining
aggregation stage soluble guanylyl cyclase sGC is mainly expressed during aggregation phase Dictyostelium discoideum
-
aggregation stage upon development, mRNA expression of guanylyl cyclase GCA decreases about 5fold during aggregation and subsequently rises, reaching a maximum during the slug stage Dictyostelium discoideum
-
slug stage upon development, mRNA expression of guanylyl cyclase GCA decreases about 5fold during aggregation and subsequently rises, reaching a maximum during the slug stage Dictyostelium discoideum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Dictyostelium discoideum 3',5'-cyclic GMP + diphosphate
-
 ?
additional information soluble guanylyl cyclase sGC provides the major guanylyl cyclase activity in Dictyostelium, contributing about 90% of the chemoattractant-induced cGMP response Dictyostelium discoideum ?
-
 ?

Synonyms

Synonyms Comment Organism
GCA
-
 Dictyostelium discoideum
guanylyl cyclase
-
 Dictyostelium discoideum
sGC
-
 Dictyostelium discoideum
soluble guanylyl cyclase
-
 Dictyostelium discoideum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00005
-
 Ca2+
-
 Dictyostelium discoideum
0.00005
-
 Ca2+ soluble guanylyl cyclase sGC Dictyostelium discoideum
0.0002
-
 Ca2+ soluble guanylyl cyclase sGC Dictyostelium discoideum