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Literature summary for 4.6.1.2 extracted from

  • Koglin, M.; Behrends, S.
    A Functional domain of the a1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding (2003), J. Biol. Chem., 278, 12590-12597.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
2,2-diethyl-1-nitroso-oxyhydrazine NO donor, 0.1 mM, 242fold activation Homo sapiens
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 0.2 mM, 80fold activation of recombinant sGC Homo sapiens
NO
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of alpha1 and beta1 subunits in Sf9 insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
DELTAN364 alpha1 DELTAN364 deletion mutant shows a complete loss of sensitivity towards NO or 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and a slight decrease in basal sGC activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.134
-
 GTP 37°C, pH 7.4, recombinant sGC Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant sGC Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Homo sapiens
soluble guanylyl cyclase
-
 Homo sapiens