Literature summary for 4.6.1.16 extracted from

Tocchini-Valentini, G.D.; Tocchini-Valentini, G.P.
Avatar pre-tRNAs help elucidate the properties of tRNA-splicing endonucleases that produce tRNA from permuted genes (2012), Proc. Natl. Acad. Sci. USA, 109, 21325-21329.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pretRNA	Schizosaccharomyces pombe	-	a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus	-	?
pretRNA	Methanocaldococcus jannaschii	-	a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus	-	?

Organism

Organism	UniProt	Comment	Textmining
Methanocaldococcus jannaschii	Q58819	-	-
Schizosaccharomyces pombe	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pretRNA	-	Schizosaccharomyces pombe	a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus	-	?
pretRNA	-	Methanocaldococcus jannaschii	a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus	-	?

Subunits

Subunits	Comment	Organism
heterotetramer	-	Schizosaccharomyces pombe
homotetramer	-	Methanocaldococcus jannaschii

Synonyms

Synonyms	Comment	Organism
MJ1424	locus name	Methanocaldococcus jannaschii
tRNA endonuclease	-	Schizosaccharomyces pombe
tRNA endonuclease	-	Methanocaldococcus jannaschii
tRNA-splicing endonuclease	-	Schizosaccharomyces pombe
tRNA-splicing endonuclease	-	Methanocaldococcus jannaschii

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Release 2023.1 (January 2023)