Literature summary for 4.6.1.14 extracted from

Xing, Y.; Gu, Y.; Xu, L.C.; Siedlecki, C.A.; Donahue, H.J.; You, J.
Effects of membrane cholesterol depletion and GPI-anchored protein reduction on osteoblastic mechanotransduction (2010), J. Cell. Physiol., 226, 2350,235-9.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MC3T3-E1 cell	-	Mus musculus	-
osteoblast	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glycosylphosphatidylinositol-anchored protein	-	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
glycosylphosphatidylinositol-specific phospholipase D	-	Mus musculus
GPI-PLD	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) specifically cleaves glycosylphosphatidylinositol-anchored proteins from cell membranes. Reduction of GPI-anchored proteins on cell membranes by over expression of GPI-PLD results in significant inhibition of intracellular Ca2+ mobilization and ERK1/2 phosphorylation in response to oscillatory fluid flow	Mus musculus

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Release 2023.1 (January 2023)