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Literature summary for 4.6.1.14 extracted from

  • Subramanya, S.; Hardin, C.F.; Steverding, D.; Mensa-Wilmot, K.
    Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome (2009), Biochem. J., 417, 685-694.
    View publication on PubMed
Search for more literature for 4.6.1.14

Protein Variants

Protein Variants Comment Organism
Q81L catalytically inactive mutant Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information GPI-PLC is not detected at endosomes Trypanosoma brucei
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei GPI-PLC is a signalling enzyme, and DAG is a second messenger for GPI-PLC. Its enzyme activity is important for stimulating uptake of transferrin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
 427 and RUMP528
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information bloodstream-form Trypanosoma brucei RUMP528 (GPI-PLC-/-) Trypanosoma brucei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GPI-PLC is a signalling enzyme, and DAG is a second messenger for GPI-PLC. Its enzyme activity is important for stimulating uptake of transferrin Trypanosoma brucei ?
-
 ?

Synonyms

Synonyms Comment Organism
glycosylphosphatidylinositol-specific phospholipase C
-
 Trypanosoma brucei
glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome, surmise that GPI-PLC regulates transferrin endocytosis in Trypanosoma brucei Trypanosoma brucei
GPI-PLC
-
 Trypanosoma brucei
GPI-PLC enzyme
-
 Trypanosoma brucei