Cloned (Comment) | Organism |
---|---|
expression in Leishmania major | Trypanosoma brucei |
Protein Variants | Comment | Organism |
---|---|---|
C184A | exhibits activity in the range detected for the unmutated protein, deficiency of cell-associated gp63, localization in endo-lysosome | Trypanosoma brucei |
C269C/C270S/C273S | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
C269S/C270S | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
C269S/C273S | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
C270S/C273S | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
C347A | exhibits activity in the range detected for the unmutated protein, deficiency of cell-associated gp63, localization in endo-lysosome | Trypanosoma brucei |
C80A | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
Q81L | inactive | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
glycosome | in case of mutations on the endosome targeting motif, glycosomal GPI-PLC from Trypanosoma brucei fails to produce the glycosylphosphatidylinositol deficiency in Leishmania major | Trypanosoma brucei | 20015 | - |
additional information | endo-lysosomal system, wild-type, endosomal GPI-PLC from Trypanosoma brucei causes a deficiency of protein glycosylphosphatidylinositols in Leishmania major | Trypanosoma brucei | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol | Trypanosoma brucei | - |
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
652 | - |
- |
Trypanosoma brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol | - |
Trypanosoma brucei | 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycosylphosphatidylinositol-specific phospholipase C | - |
Trypanosoma brucei |
GPI-PLC | - |
Trypanosoma brucei |