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Literature summary for 4.6.1.14 extracted from

  • Müller, G.; Schulz, A.; Wied, S.; Frick, W.
    Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes (2005), Biochem. Pharmacol., 69, 761-780.
    View publication on PubMed
Search for more literature for 4.6.1.14

Inhibitors

Inhibitors Comment Organism Structure
2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid GPI-1793 Bacillus cereus
2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid GPI-1793 Trypanosoma brucei
additional information low inhibition by 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid (GPI-1793) and very low inhibition by myo-inositol-1-O-dodecylphosphonic acid methylester (GPI-2349) Rattus norvegicus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid GPI-2350 Bacillus cereus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid GPI-2350 Rattus norvegicus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid GPI-2350 Trypanosoma brucei
myo-inositol-1-O-dodecylphosphonic acid methylester GPI-2349 Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol Rattus norvegicus
-
 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol Trypanosoma brucei
-
 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol Bacillus cereus
-
 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus cereus
-
-
-
Rattus norvegicus
-
-
-
Trypanosoma brucei
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 in high cholesterol-containing detergent-soluble glycolipid-enriched membrane microdomains: 488% of the activity measured in plasma membranes, in low cholesterol-containing detergent-soluble glycolipid-enriched membrane microdomains: 141% of the activity measured in plasma membranes, in non-detergent-soluble glycolipid-enriched membrane microdomains: 29% of the activity measured in plasma membranes Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
 Rattus norvegicus 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
 Trypanosoma brucei 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
 Bacillus cereus 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol the assay contains acetylcholinesterase Rattus norvegicus 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?

Synonyms

Synonyms Comment Organism
glycosylphosphatidylinositol-specific phospholipase C
-
 Rattus norvegicus
glycosylphosphatidylinositol-specific phospholipase C
-
 Trypanosoma brucei
glycosylphosphatidylinositol-specific phospholipase C
-
 Bacillus cereus
GPI-PLC
-
 Rattus norvegicus
GPI-PLC
-
 Trypanosoma brucei
GPI-PLC
-
 Bacillus cereus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0006
-
 myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
-
 Rattus norvegicus