Literature summary for 4.6.1.12 extracted from

Illarionova, V.; Kaiser, J.; Ostrozhenkova, E.; Bacher, A.; Fischer, M.; Eisenreich, W.; Rohdich, F.
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods (2006), J. Org. Chem., 71, 8824-8834.

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Application

Application	Comment	Organism
analysis	high-throughput method for the screening of 2C-methyl-D-erythritol synthase, IspC protein, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, IspD protein, 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, IspE protein, and 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, IspF protein, against large compound libraries	Plasmodium sp.
synthesis	preparation of 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate in multigram quantities	Plasmodium sp.

Organism

Organism	UniProt	Comment	Textmining
Plasmodium sp.	-	-	-

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Release 2023.1 (January 2023)