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Literature summary for 4.5.1.1 extracted from
- DDT dehydrochlorinase. I. Isolation, chemical properties, and spectrophotometric assay (1959), J. Biol. Chem., 234, 2123-2128.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GSH | required | Musca domestica |  |
| GSH | Km: 0.25 mM | Musca domestica | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 120000 | - |
PAGE | Musca domestica |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane | Musca domestica | - |
? | - |
? | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| organic solvents | instability of the enzyme to organic solvents at temperatures about -5°C | Musca domestica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Musca domestica | - |
DDT-restistant housedly | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Musca domestica |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Musca domestica |
Storage Stability
| Storage Stability | Organism |
|---|---|
| instability of the enzyme to freezing and thawing | Musca domestica |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane | i.e. 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane, i.e. DDT in the presence of GSH | Musca domestica | 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + HCl | i.e. 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene i.e. DDE | ir | |
| 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane | - |
Musca domestica | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0383 | - |
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane | - |
Musca domestica | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Musca domestica |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 6 | stable between for 6 h | Musca domestica |
| 6 | 12 | stable between for 48 h at 2°C | Musca domestica |
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