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Literature summary for 4.4.1.5 extracted from

  • Wortmann, M.; Peters, A.S.; Hakimi, M.; Boeckler, D.; Dihlmann, S.
    Glyoxalase I (Glo1) and its metabolites in vascular disease (2014), Biochem. Soc. Trans., 42, 528-533.
    View publication on PubMed
Search for more literature for 4.4.1.5

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + methylglyoxal Mus musculus
-
 (R)-S-lactoylglutathione
-
 ?
glutathione + methylglyoxal Homo sapiens
-
 (R)-S-lactoylglutathione
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Homo sapiens
-
aorta aortic sinus derived from apolipoprotein-E-knockout mouse on a high-fat diet for 6 months, enzyme expression is restricted to a subset of cells Mus musculus
-
cardiomyocyte high expression level Mus musculus
-
endothelial cell
-
 Mus musculus
-
endothelial cell
-
 Homo sapiens
-
heart
-
 Mus musculus
-
lymphocyte
-
 Homo sapiens
-
macrophage
-
 Mus musculus
-
macrophage
-
 Homo sapiens
-
podocyte
-
 Mus musculus
-
podocyte
-
 Homo sapiens
-
pulmonary artery
-
 Mus musculus
-
pulmonary artery carotid sample derived from thromboendarterectomy Homo sapiens
-
smooth muscle cell medial, high expression level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + methylglyoxal
-
 Mus musculus (R)-S-lactoylglutathione
-
 ?
glutathione + methylglyoxal
-
 Homo sapiens (R)-S-lactoylglutathione
-
 ?

Synonyms

Synonyms Comment Organism
Glo1
-
 Mus musculus
Glo1
-
 Homo sapiens
glyoxalase I
-
 Mus musculus
glyoxalase I
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction increased methylglyoxal levels, resulting from decreased enzyme activity, induce apoptosis in fully differentiated podocytes, as well as in endothelial cells and macrophages in hypoxic regions of atherosclerotic arteries Mus musculus
malfunction increased methylglyoxal levels, resulting from decreased enzyme activity, induce apoptosis in fully differentiated podocytes, as well as in endothelial cells and macrophages in hypoxic regions of atherosclerotic arteries Homo sapiens
metabolism the glyoxalase system is composed of glyoxalase I, glyoxalase II, and glutathione as cofactor Mus musculus
metabolism the glyoxalase system is composed of glyoxalase I, glyoxalase II, and glutathione as cofactor Homo sapiens
physiological function the enzyme is part of the glyoxylate system, whose function is to detoxify reactive metabolites, which mainly accumulate during hyperglycaemic metabolism, major substrate is methylglyoxal. The mean glyoxalase I activity of atherosclerotic tissue from aortic and coronary artery samples is significantly reduced compared with healthy tissue derived from the same vessel, indicating a role for glyoxalase I in atherogenesis, the enzyme plays a role in inflammatory response, hypertension, and diabetic microvascular complications, overview Mus musculus
physiological function the enzyme is part of the glyoxylate system, whose function is to detoxify reactive metabolites, which mainly accumulate during hyperglycaemic metabolism, major substrate is methylglyoxal. The mean glyoxalase I activity of atherosclerotic tissue from aortic and coronary artery samples is significantly reduced compared with healthy tissue derived from the same vessel, indicating a role for glyoxalase I in atherogenesis, the enzyme plays a role in inflammatory response, hypertension, and diabetic microvascular complications, overview Homo sapiens