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Literature summary for 4.4.1.5 extracted from

  • Thornalley, P.J.; Waris, S.; Fleming, T.; Santarius, T.; Larkin, S.J.; Winklhofer-Roob, B.M.; Stratton, M.R.; Rabbani, N.
    Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance (2010), Nucleic Acids Res., 38, 5432-5442.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methylglyoxal + glutathione Homo sapiens
-
(R)-S-lactoylglutathione
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
MG-63 cell
-
Homo sapiens
-
NCI-H460 cell
-
Homo sapiens
-
NCI-H522 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + glutathione
-
Homo sapiens (R)-S-lactoylglutathione
-
?

Synonyms

Synonyms Comment Organism
Glo1
-
Homo sapiens
glyoxalase-1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
glutathione
-
Homo sapiens