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Literature summary for 4.4.1.5 extracted from

  • Louie, B.; Rajamahanty, S.; Pyo, P.; Choudhury, M.; Konno, S.
    Mode of cytotoxic action of nephrotoxic agents: oxidative stress and glutathione-dependent enzyme (2010), BJU Int., 105, 264-268.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
buthionine sulfoximine 58% loss in Gly-I activity by 0.05 mM buthionine sulfoximine Homo sapiens
glycerol 64% loss in Gly-I activity by 2.5% (v/v) glycerol, Gly-I inactivation by glycerol is fully prevented or reversed by 0.5 mM N-acetylcysteine Homo sapiens
HgCl2 67% loss in Gly-I activity by 0.03 mM HgCl2, Gly-I inactivation by HgCl2 is fully prevented or reversed by 0.5 mM N-acetylcysteine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LLC-PK cell
-
Homo sapiens
-
renal proximal tubule
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + glutathione
-
Homo sapiens (R)-S-lactoylglutathione
-
?

Synonyms

Synonyms Comment Organism
gly-I
-
Homo sapiens
glyoxalase I
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
glutathione
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Gly-I activity in N-acetylcysteine-exposed cells is 40% higher than that in control cells up

General Information

General Information Comment Organism
physiological function Gly-I plays a key role in cellular detoxification Homo sapiens