Literature summary for 4.4.1.5 extracted from

Liu, M.; Yuan, M.; Luo, M.; Bu, X.; Luo, H.B.; Hu, X.
Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis (2010), Biophys. Chem., 147, 28-34.

Search for more literature for 4.4.1.5

Inhibitors

Inhibitors	Comment	Organism	Structure
bisdemethoxycurcumin	-	Homo sapiens
curcumin	efficient inhibitor	Homo sapiens
indomethacin	-	Homo sapiens
S-(N-hydroxy-N-p-iodophenylcarbamoyl) glutathione	tight binding competitive inhibitor of human GLOI	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q04760	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
methylglyoxal + glutathione	-	Homo sapiens	S-D-lactoylglutathione	-	?

Synonyms

Synonyms	Comment	Organism
GloI	-	Homo sapiens
glyoxalase I	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
glutathione	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0103	-	bisdemethoxycurcumin	-	Homo sapiens
0.0182	-	curcumin	-	Homo sapiens
0.0244	-	indomethacin	-	Homo sapiens

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Release 2023.1 (January 2023)