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Literature summary for 4.4.1.5 extracted from

  • Takatsume, Y.; Ohdate, T.; Maeta, K.; Nomura, W.; Izawa, S.; Inoue, Y.
    Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca2+ in Saccharomyces cerevisiae (2010), Biochem. J., 427, 275-287.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methylglyoxal + glutathione Saccharomyces cerevisiae
-
 (R)-S-lactoylglutathione
-
 ?
methylglyoxal + glutathione Saccharomyces cerevisiae YPH250
-
 (R)-S-lactoylglutathione
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae YPH250
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + glutathione
-
 Saccharomyces cerevisiae (R)-S-lactoylglutathione
-
 ?
methylglyoxal + glutathione
-
 Saccharomyces cerevisiae YPH250 (R)-S-lactoylglutathione
-
 ?

Synonyms

Synonyms Comment Organism
Glo1
-
 Saccharomyces cerevisiae
glyoxalase I
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
glutathione
-
 Saccharomyces cerevisiae

Expression

Organism Comment Expression
Saccharomyces cerevisiae the expression of GLO1 is induced following treatment with Ca2+ and is dependent on the mitogen-activated protein kinase Hog1 protein and the Msn2/Msn4 transcription factors, the Ca2+-induced expression of GLO1 is enhanced in the presence of FK506 up