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Literature summary for 4.4.1.5 extracted from
- Taurine enhances the metabolism and detoxification of ethanol and prevents hepatic fibrosis in rats treated with iron and alcohol (2009), Environ. Toxicol. Pharmacol., 27, 120-126.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no change in glyoxalase I activity in taurine-treated rats, 2% (w/v) | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no change in glyoxalase I activity in taurine-treated rats | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male albino rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | homogenate | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 8.69 | - |
addition of 6 g/kg ethanol and iron, 57% activity of control without ethanol and iron | Rattus norvegicus |
| 10.36 | - |
addition of 6 g/kg ethanol, 68% activity of control without ethanol | Rattus norvegicus |
| 12.01 | - |
addition of 6 g/kg ethanol, iron, and 2% (w/v) taurine, 68% activity of control without ethanol, iron, and taurine | Rattus norvegicus |
| 13.34 | - |
addition of 6 g/kg ethanol and 2% (w/v) taurine, 79% activity of control without ethanol and taurine | Rattus norvegicus |
| 15.24 | - |
without addition of ethanol, iron, or taurine | Rattus norvegicus |
| 15.62 | - |
addition of 2% (w/v) taurine, 102% activity of control without ethanol, iron, or taurine | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methylglyoxal + glutathione | liver homogenate, the effects of taurine, ethanol, and iron alone or in combination are analyzed, pH 7.0, 37°C | Rattus norvegicus | S-((R)-lactoyl)glutathione | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glyoxalase I | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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