Inhibitors | Comment | Organism | Structure |
---|---|---|---|
baicalein | 79% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
Baicalin | 30% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
hyperin | below 5% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
kaempferol | 60% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
luteolin | 90% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
myricetin | 75% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
naringenin | 50% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
oroxylin A | 140% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
quercetin | 78% inhibition of rhGLO I at 0.1 mM | Homo sapiens | |
S-p-bromobenzylglutathione | 55% inhibition of rhGLO I at 0.1 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q04760 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylglyoxal + glutathione | - |
Homo sapiens | S-((R)-lactoyl)glutathione | determined monitoring the increase in absorbance at 240 nm for 5 min at 25°C, pH 7.0 | ? |
Synonyms | Comment | Organism |
---|---|---|
GLO I | - |
Homo sapiens |
glyoxalase I | - |
Homo sapiens |
rhGLO I | His-tagged GLO I protein | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00056 | - |
indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 | Homo sapiens | myricetin | |
0.0032 | - |
indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 | Homo sapiens | quercetin | |
0.007 | - |
indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 | Homo sapiens | luteolin | |
0.011 | - |
indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 | Homo sapiens | baicalein | |
0.0206 | - |
indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0 | Homo sapiens | kaempferol | |
0.023 | - |
calculated, effectively inhibits rhGLO I at 25°C, pH 7.0 | Homo sapiens | S-p-bromobenzylglutathione |