Literature summary for 4.4.1.5 extracted from

Kuhla, B.; Boeck, K.; Schmidt, A.; Ogunlade, V.; Arendt, T.; Muench, G.; Lueth, H.J.
Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimers disease brains (2007), Neurobiol. Aging, 28, 29-41.

Search for more literature for 4.4.1.5

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	glyoxalase I protein amounts are 1.5fold increased in early Alzheimers disease subjects	Homo sapiens

Application

Application	Comment	Organism
medicine	decrease of glyoxalase I expression with increasing Alzheimers disease stage might be one reason for methylglyoxal-induced neuronal impairment, apoptosis, and advanced glycation end formation in plaques and tangles	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	reducing glyoxalase I RNA levels with advancing stage of Alzheimers disease and with increasing age, continuously decrease in middle and late stages of Alzheimers disease, glyoxalase I activity neither significantly changes with age nor with the course of the disease	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	Brodmann area 22, glyoxalase I levels are diminished in old aged brains but elevated in Alzheimers disease brains, Brodmann area 28, elevated amounts of advanced glycation end staining and decreased levels of glyoxalase I with advancing stage of Alzheimers disease	Homo sapiens	-
cerebral cortex	-	Homo sapiens	-
neuron	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione + methylglyoxal	-	Homo sapiens	S-D-lactoylglutathione	-	?

Synonyms

Synonyms	Comment	Organism
glyoxalase I	-	Homo sapiens

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Release 2023.1 (January 2023)