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Literature summary for 4.4.1.5 extracted from
- Overexpression of glyoxalase system enzymes in human kidney tumor (2006), Cancer J., 12, 222-228.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | possible role of glyoxalase I in the chemoresistance displayed by kidney tumor, possible use of glyoxalase I inhibitors as anticancer drugs, increase in glyoxalase I lowers level of the potent apoptosis activator methylglyoxal | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | Q04760 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
| kidney tumor cell | transcription level and glyoxalase I activity are higher in pathological tissues than in normal ones | Homo sapiens | - |
| additional information | renal carcinoma cell, clear cell adenocarcinoma, 9fold increase in the transcription levels of glyoxalase I compared with pair-matched noncancerous tissues | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + methylglyoxal | - |
Homo sapiens | S-lactoylglutathione | - |
? |  |
| glutathione + methylglyoxal | - |
Homo sapiens | S-D-lactoylglutathione | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glyoxalase I | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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