Application | Comment | Organism |
---|---|---|
drug development | design of a metabolically stable glyoxalase-I inhibitor, which may be useful in potentiating the antitumor activity of alpha-ketoaldehydes | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-gamma-glutamyl-S-[(4-bromophenyl)(hydroxy)carbamoyl]-L-cysteinylglycine | hydroxamic acid-based transition state inhibitor, unstable toward gamma-glutamyltranspeptidase | Saccharomyces cerevisiae | |
N-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-S-[(4-bromophenyl)(hydroxy)carbamoyl]-L-cysteinylglycine | tight-binding competitive inhibitor, stable toward gamma-glutamyltranspeptidase | Saccharomyces cerevisiae | |
S-p-bromobenzyl glutathione | competitive inhibitor, unstable toward gamma-glutamyltranspeptidase | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.35 | - |
glutathione | - |
Saccharomyces cerevisiae | |
0.35 | - |
methylglyoxal | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + methylglyoxal | - |
Saccharomyces cerevisiae | S-D-lactoylglutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glx-I | - |
Saccharomyces cerevisiae |
glyoxalase-I | - |
Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.6 | - |
- |
Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00219 | - |
N-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-S-[(4-bromophenyl)(hydroxy)carbamoyl]-L-cysteinylglycine | - |
Saccharomyces cerevisiae |