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Literature summary for 4.4.1.5 extracted from

  • Shinohara, M.; Thornalley, P.J.; Giardino, I.; Beisswenger, P.; Thorpe, S.R.; Onorato, J.; Brownlee, M.
    Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis (1998), J. Clin. Invest., 101, 1142-1147.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens overexpression of the enzyme completely prevents both hyperglycemia-induced advanced glycation products from methylglyoxal and increased macromolecular endocytosis ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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expressed in bovine aortic endothelial cells
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information overexpression of the enzyme completely prevents both hyperglycemia-induced advanced glycation products from methylglyoxal and increased macromolecular endocytosis Homo sapiens ?
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?