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Literature summary for 4.4.1.5 extracted from
- Purification and kinetic study of glyoxalase-I from rat liver, erythrocytes, brain and kidney (1976), Biochim. Biophys. Acta, 445, 486-499.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
p-methoxyphenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus |  |
| 0.02 | - |
p-chlorophenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.02 | - |
p-phenylphenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.02 | - |
4-bromophenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.02 | - |
4-methylphenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.03 | - |
p-hydroxyphenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.03 | - |
m-methoxyphenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.04 | - |
Phenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.07 | - |
2,4-dimethylphenylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.09 | - |
methylglyoxal | liver or erythrocyte enzyme | Rattus norvegicus | |
| 0.2 | - |
kethoxal | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
liver and erythrocyte enzyme, gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | intramolecular hydride migration is the rate-determining step | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| erythrocyte | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 191 | - |
kidney enzyme | Rattus norvegicus |
| 814 | - |
brain enzyme | Rattus norvegicus |
| 983 | - |
liver enzyme | Rattus norvegicus |
| 2410 | - |
- |
Rattus norvegicus |
| 2415 | - |
erythrocyte enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 2,4-dimethylphenylglyoxal | - |
Rattus norvegicus | S-(2,4-dimethyl)mandeloylglutathione | - |
? | |
| glutathione + 4-bromophenylglyoxal | - |
Rattus norvegicus | S-(4-bromo)mandeloylglutathione | - |
? | |
| glutathione + 4-methylphenylglyoxal | - |
Rattus norvegicus | S-(4-methyl)mandeloylglutathione | - |
? | |
| glutathione + bromophenylglyoxal | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + kethoxal | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + m-methoxyphenylglyoxal | - |
Rattus norvegicus | S-(3-methoxy)mandeloylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Rattus norvegicus | S-lactoylglutathione | - |
? | |
| glutathione + methylphenylglyoxal | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + p-chlorophenylglyoxal | - |
Rattus norvegicus | S-(4-chloro)mandeloylglutathione | - |
? | |
| glutathione + p-hydroxyphenylglyoxal | - |
Rattus norvegicus | S-(4-hydroxy)mandeloylglutathione | - |
? | |
| glutathione + p-methoxyphenylglyoxal | - |
Rattus norvegicus | S-(4-methoxy)mandeloylglutathione | - |
? | |
| glutathione + p-phenylphenylglyoxal | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + phenylglyoxal | - |
Rattus norvegicus | S-mandeloylglutathione | - |
? | |
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