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Literature summary for 4.4.1.5 extracted from
- The glyoxalase system (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, 3, 597-641.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | - |
Escherichia coli | |
| additional information | - |
Homo sapiens | |
| additional information | - |
Mus musculus | |
| additional information | - |
Oryctolagus cuniculus | |
| additional information | - |
Ovis aries | |
| additional information | - |
Rattus norvegicus | |
| additional information | - |
Rhodospirillum rubrum | |
| additional information | - |
Saccharomyces cerevisiae | |
| additional information | - |
Sus scrofa |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Mus musculus | |
| additional information | - |
additional information | - |
Escherichia coli | |
| additional information | - |
additional information | - |
Homo sapiens | |
| additional information | - |
additional information | - |
Rattus norvegicus | |
| additional information | - |
additional information | - |
Sus scrofa | |
| additional information | - |
additional information | - |
Saccharomyces cerevisiae | |
| additional information | - |
additional information | - |
Oryctolagus cuniculus | |
| additional information | - |
additional information | - |
Ovis aries | |
| additional information | - |
additional information | - |
Rhodospirillum rubrum | |
| 0.06 | - |
alpha-deuteriophenylglyoxal | - |
Saccharomyces cerevisiae |  |
| 0.19 | - |
perdeuteriomethylglyoxal | - |
Saccharomyces cerevisiae | |
| 0.2 | - |
Phenylglyoxal | - |
Saccharomyces cerevisiae | |
| 0.32 | - |
methylglyoxal | - |
Saccharomyces cerevisiae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metalloenzymes | Homo sapiens | |
| Zn2+ | zinc metalloenzymes | Rattus norvegicus | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Mus musculus | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Escherichia coli | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Homo sapiens | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Rattus norvegicus | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Sus scrofa | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Saccharomyces cerevisiae | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Oryctolagus cuniculus | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Ovis aries | |
| Zn2+ | metalloenzyme with one Zn2+ per subunit | Rhodospirillum rubrum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 31000 | - |
- |
Rhodospirillum rubrum |
| 34000 | - |
- |
Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Ovis aries | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Rhodospirillum rubrum | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Sus scrofa | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Mus musculus | |
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Escherichia coli | |
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Homo sapiens | |
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Rattus norvegicus | |
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Sus scrofa | |
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Saccharomyces cerevisiae | |
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Oryctolagus cuniculus | |
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Ovis aries | |
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Rhodospirillum rubrum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Homo sapiens | - |
| adrenal gland | - |
Homo sapiens | - |
| aorta | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| diaphragm | - |
Homo sapiens | - |
| erythrocyte | - |
Mus musculus | - |
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Rattus norvegicus | - |
| erythrocyte | - |
Sus scrofa | - |
| erythrocyte | - |
Oryctolagus cuniculus | - |
| erythrocyte | - |
Ovis aries | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Ovis aries | - |
| lung | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 565 | - |
- |
Mus musculus |
| 681 | - |
- |
Oryctolagus cuniculus |
| 950 | - |
liver | Rattus norvegicus |
| 957 | - |
- |
Sus scrofa |
| 2110 | - |
erythrocytes | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + methylglyoxal | - |
Mus musculus | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Escherichia coli | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Homo sapiens | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Rattus norvegicus | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Sus scrofa | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Saccharomyces cerevisiae | S-lactoylglutathione | - |
? | |
| glutathione + methylglyoxal | - |
Ovis aries | S-lactoylglutathione | - |
? | |
| glutathione + p-chlorophenylglyoxal | - |
Rattus norvegicus | S-(4-chloro)mandeloylglutathione | - |
? | |
| glutathione + p-chlorophenylglyoxal | - |
Saccharomyces cerevisiae | S-(4-chloro)mandeloylglutathione | - |
? | |
| glutathione + phenylglyoxal | - |
Saccharomyces cerevisiae | S-mandeloylglutathione | - |
? | |
| additional information | activity with glutathione analogs | Mus musculus | ? | - |
? | |
| additional information | activity with glutathione analogs | Escherichia coli | ? | - |
? | |
| additional information | activity with glutathione analogs | Homo sapiens | ? | - |
? | |
| additional information | activity with glutathione analogs | Rattus norvegicus | ? | - |
? | |
| additional information | activity with glutathione analogs | Sus scrofa | ? | - |
? | |
| additional information | activity with glutathione analogs | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | activity with glutathione analogs | Oryctolagus cuniculus | ? | - |
? | |
| additional information | activity with glutathione analogs | Ovis aries | ? | - |
? | |
| additional information | activity with glutathione analogs | Rhodospirillum rubrum | ? | - |
? | |
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