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Literature summary for 4.4.1.34 extracted from

  • Van Hylckama Vlieg, J.; Kingma, J.; Kruizinga, W.; Janssen, D.
    Purification of a glutathione S-transferase and a glutathione conjugate-specific dehydrogenase involved in isoprene metabolism in Rhodococcus sp. strain AD45 (1999), J. Bacteriol., 181, 2094-2101.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.4.1.34

Application

Application Comment Organism
degradation enzyme is involved in degradation of primary oxidation products of isoprene, cis-1,2-dichloroethanol, and trans-1,2-dichloroethanol Rhodococcus sp.

Inhibitors

Inhibitors Comment Organism Structure
1,2-Epoxybutane addition of low concentrations of 1,2-epoxybutane and 1,2-epoxyhexane strongly inhibits growth on isoprene but not growth on ethanol and irreversibly inhibits the epoxide-degrading activity Rhodococcus sp.
1,2-epoxyhexane addition of low concentrations of 1,2-epoxybutane and 1,2-epoxyhexane strongly inhibits growth on isoprene but not growth on ethanol and irreversibly inhibits the epoxide-degrading activity Rhodococcus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione Rhodococcus sp.
-
 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol
-
 ?
cis-1,2-dichloroepoxyethane + glutathione Rhodococcus sp.
-
 1,2-dichloro-2-(glutathion-S-yl)-ethan-1-ol
-
 ?
epoxypropane + glutathione Rhodococcus sp.
-
 2-(glutathion-S-yl)-propan-1-ol
-
 ?
trans-1,2-dichloroepoxyethane + glutathione Rhodococcus sp.
-
 1,2-dichloro-2-(glutathion-S-yl)-ethan-1-ol
-
 ?

Organism

Organism UniProt Comment Textmining
Rhodococcus sp. Q9RBP4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione
-
 Rhodococcus sp. 2-(glutathion-S-yl)-2-methylbut-3-en-1-ol
-
 ?
cis-1,2-dichloroepoxyethane + glutathione
-
 Rhodococcus sp. 1,2-dichloro-2-(glutathion-S-yl)-ethan-1-ol
-
 ?
epoxypropane + glutathione
-
 Rhodococcus sp. 2-(glutathion-S-yl)-propan-1-ol
-
 ?
trans-1,2-dichloroepoxyethane + glutathione
-
 Rhodococcus sp. 1,2-dichloro-2-(glutathion-S-yl)-ethan-1-ol
-
 ?

Synonyms

Synonyms Comment Organism
IsoI
-
 Rhodococcus sp.

General Information

General Information Comment Organism
physiological function the enzyme is a glutathione S-transferase involved in the metabolism of isoprene and able to detoxify reactive epoxides produced by monooxygenation of chlorinated ethenes Rhodococcus sp.