Literature summary for 4.4.1.21 extracted from

Cao, M.; Feng, Y.; Wang, C.; Zheng, F.; Li, M.; Liao, H.; Mao, Y.; Pan, X.; Wang, J.; Hu, D.; Hu, F.; Tang, J.
Functional definition of LuxS, an autoinducer-2 (AI-2) synthase and its role in full virulence of Streptococcus suis serotype 2 (2011), J. Microbiol., 49, 1000-1011.

Search for more literature for 4.4.1.21

Cloned(Commentary)

Cloned (Comment)	Organism
gene luxS, sequence comparisons, expression and transcriptome analysis of wild-type and enzyme knockout mutant strains	Streptococcus suis

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of a luxS null mutant of 05ZYH33 strain is obtained by homologous recombination	Streptococcus suis

Organism

Organism	UniProt	Comment	Textmining
Streptococcus suis	A4VTE8	serotype 2, gene luxS	-
Streptococcus suis 05ZYH33	A4VTE8	serotype 2, gene luxS	-

Synonyms

Synonyms	Comment	Organism
AI-2 synthase	-	Streptococcus suis
autoinducer-2 synthase	-	Streptococcus suis
Lux S	-	Streptococcus suis

General Information

General Information	Comment	Organism
malfunction	inactivation of luxS gene leads to a wide range of phenotypic changes including thinner capsular walls, increased tolerance to H2O2, reduced adherence capacity to epithelial cells. In particular, loss of LuxS impairs dramatically full virulence of serotype 2 in experimental model of piglets, and functional complementation restores virulence nearly to the level of parent strain	Streptococcus suis
additional information	modeling of enzyme protein structure and luxS-mediated global regulation using the genome-wide microarray analyses, overview	Streptococcus suis
physiological function	the enzyme is required for synthesis of autoinducer 2, a signaling molecule for inter-species quorum sensing. Cell adherence analyses with human laryngeal epithelial cell line Hep-2 and human umbilical vein endothelial cells	Streptococcus suis

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Release 2023.1 (January 2023)