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Literature summary for 4.4.1.21 extracted from

  • Wilson, C.M.; Aggio, R.B.; OToole, P.W.; Villas-Boas, S.; Tannock, G.W.
    Transcriptional and metabolomic consequences of LuxS inactivation reveal a metabolic rather than quorum-sensing role for LuxS in Lactobacillus reuteri 100-23 (2012), J. Bacteriol., 194, 1743-1746.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information generation of a knockout mutant by insertional mutation of the luxS gene, transcriptomic and metabolomic changes of wild-type and mutant strains, overview Limosilactobacillus reuteri

Organism

Organism UniProt Comment Textmining
Limosilactobacillus reuteri B3XKW0 gene luxS
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Limosilactobacillus reuteri 100-23 B3XKW0 gene luxS
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Synonyms

Synonyms Comment Organism
AI-2 synthase
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 Limosilactobacillus reuteri
LuxS
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 Limosilactobacillus reuteri

General Information

General Information Comment Organism
malfunction transcriptomic and metabolomic changes of wild-type enzyme and an insertional knockout mutant strains, especially expression of lipoproteins of the YaeC family and cysteine synthase are affected, overview Limosilactobacillus reuteri
physiological function two potential roles for the enzyme, the first is in the production of autoinducer-2, mediating quorum sensing, and the second is as an enzyme in the activated methyl cycle, where it catalyzes the conversion of S-ribosylhomocysteine to homocysteine. The by-product of the reaction catalyzed by the enzyme is (S)-4,5-dihydroxy-2,3-pentanedione, which spontaneously forms the furanones known collectively as autoinducer-2, AI-2 Limosilactobacillus reuteri