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Literature summary for 4.4.1.21 extracted from

  • Doherty, N.C.; Shen, F.; Halliday, N.M.; Barrett, D.A.; Hardie, K.R.; Winzer, K.; Atherton, J.C.
    In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathway (2010), J. Bacteriol., 192, 1184-1192.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Helicobacter pylori
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General Information

General Information Comment Organism
physiological function isogenic strains carrying mutations in luxS or its neighboring genes cysK, and metB can not grow without added cysteine, suggesting roles in cysteine synthesis. Growth of the DELTAluxSHp mutant is restored by homocysteine or cystathionine. S-ribosylhomocysteine accumulates in the DELTAluxS mutant, suggesting that in Helicobacter pylori, S-ribosylhomocysteine is converted by LuxS to homocysteine as in the classic activated methyl cycle, and thence by CysK to cystathionine and by MetB to cysteine Helicobacter pylori