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Literature summary for 4.4.1.21 extracted from

  • Trappetti, C.; Potter, A.J.; Paton, A.W.; Oggioni, M.R.; Paton, J.C.
    LuxS mediates iron-dependent biofilm formation, competence and fratricide in Streptococcus pneumoniae (2011), Infect. Immun., 79, 4550-4558.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Fe(III) Fe(III) upregulates expression of luxS and Fe(III) strongly enhances biofilm formation at concentrations above 50 microM Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
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Expression

Organism Comment Expression
Streptococcus pneumoniae Fe(III) upregulates expression of luxS and Fe(III) strongly enhances biofilm formation at concentrations above 50 microM up

General Information

General Information Comment Organism
physiological function Fe(III) upregulates expression of luxS and Fe(III) strongly enhances biofilm formation at concentrations above 50 microM. A luxS-deficient mutant fails to form a biofilm, even with Fe(III) supplementation, whereas a derivative over-expressing luxS exhibits enhanced biofilm formation capacity, and can form a biofilm without added Fe(III). The luxS-deficient mutant exhibits reduced expression of the major Fe(III) transporter PiuA, and cellular cencentration of Fe(III) is significantly lower than in wild-type. The luxS overexpressing mutant has a significantly higher cellular concentration of Fe(III) than the wild-type. Release of extracellular DNA, which is an important component of the biofilm matrix, is also directly related to luxS expression. Genetic competence, as well as expression of competence genes comD, comX, comW, cglA and dltA, and the murein hydrolase cbpD associated with fratricide-dependent DN release, are all directly related to luxS expression levels, and further up-regulated by Fe(III) Streptococcus pneumoniae